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The Chemistry building has recently undergone extensive refurbishment
and provides modern facilities for about 300 students reading for the
taught undergraduate (MChem and
BSc) or postgraduate (MSc) programmes
together with typically 10 postdoctoral research fellows, 70 postgraduate
research workers (MPhil and PhD) and 25 academic staff.
In addition to laboratories servicing the teaching and research
needs of analytical, organic, inorganic and physical chemistry, specialist
teaching and research laboratories are available within the department
for radiochemistry, polymer chemistry, analytical chemistry, microbiology
and molecular pharmacology.
The Department has a number of specialist instruments and facilities
including:
NMR Spectrometers:
Bruker DPX-400, Bruker Avance Ultra-Shield 400 and Bruker Avance 500,
Solid-State NMR spectrometer.
We run proton, carbon, DEPT, COSY and HMQC via open-access automation
on the using a gradients dual probe fitted to the DPX-400.
Selective shaped-pulse 1D variants of COSY, TOCSY, HMQC, HMBC, nOe and
H2BC, HET-LOC, JRES, and DOSY are run using a BBO ATMA gradients probe
fitted to the Av400.
Solid state NMR spectra are recorded on the 500MHz spectrometer, which
is fitted with a 4mm HX probe(MAS up to 15kHz) and a 2.5mm HX probe(MAS
up to 35kHz).
We routinely record CP-MAS, DP-MAS, TOSS, dipolar dephasing, CP-build
up, MAS-J-HMQC, and MQ-MAS.
X-Ray: Single crystal X-ray diffraction.
Bruker APEX 2 CCD diffractometer with Oxford Cryosystems low temperature
device.
Structure determination from a single crystal, typically within 24 hours.
Absolute structure determination for samples with atomic number greater
than ca. 14.
Mass Spectrometry:
Sector field organic mass spectrometry, LC-MS and GC-MS and two recent
acquisitions are:
SF-ICP-MS
The image is of a sector-field, high resolution, inductively-coupled plasma
mass spectrometer. The technique is given the acronym SF-ICP-MS. These
instruments are used for elemental analysis and can detect concentrations
down to ~10-13 grams per ml of the majority of elements in the periodic
table. They are one of the most sensitive analytical instruments available
and have applications in bio- and medical science, environmental science,
food and nuclear science.
Linear Ion Trap LC-MS
The image shows a modern, state-of-the-art, organic mass spectrometer
with on-line liquid chromatography. The technique is referred to as LC-MS.
This particular mass spectrometer incorporates a trap where ions can be
stored and fragmented by collisions to determine their structure. Applications
of this technique include the study of drug metabolism, elucidation of
the structure of proteins and DNA and the determination of trace organic
molecules in the environment.
In addition the Department has an extensive range of modern analytical
equipment including instrumentation for separation techniques: LC, GC,
HPLC, CE, PAGE, SPE, SPME; molecular spectroscopy UV-VIS, fluorescence,
FTIR and Raman and atomic spectrometry AAS, FES and ICP-MS.
A large and well equipped computer room is also available in the main
Chemistry building for the use of students of the department during normal
working hours.
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